• A fixed-bed bioreactor consists of a media-conditioning vessel from Duran-Glass and fixed-bed with necessary macro-porous substrate for the adhering and growth of the cells. The cells grow in, around and between the porous fixed-bed materials.
  
• The fixed-bed is fitted in the conditioning vessel central and space-saving.
  
• With exception of 100 ml mini fixed-bed reactor with 10 ml fixed-bed volume are all other bioreactors equipped with temperature, pO2 and PH probes and regulator for the media-conditioning.
• The fixed-bed bioreactor system can be scaled up from laboratory up to the industrial scale.
  
• Standard sizes of bioreactors are 1 l, 2.5 l, 5 l, 10 l, 17.5 l, fixed-bed volumes are 100 ml up to 6.5 l depending on bioreactor-types.
  
• Other sizes can be offered depending on enquiry.
  
• The fixed-bed systems can be used in a continuous long time cultivation, Batch or Fedbatch cultivation with a high sterile standard and safety.
• In the long-time cultivation get the users a high cell density up to 10⁸ cells/ml.
• The cells recover rapidly after disturbance-phases.
• The fermenters can be adapted at different cell lines and are independently of expensive disposable parts such as hollow fibre systems.
  
• They are suitable for the long time cultivation of the cells under controlled conditions.
• The bioreactor systems are optimally suitable for cell cultivation in serum free nursing media.
• Different fixed-bed materials can be used in the medorex fixed-bed reactors.
  
• Our systems reduce the costs optimally because of the long time and multiple use of the fixed-bed-reactors.
  
• The fixed-bed bioreactors can be upgraded with an additional substrate and harvest pump for the continuous cell cultivation.

"Multiferm"a new multiple cell culture bioreactor for medical and scientific pretesting and tests

"Multiferm" is an automated and easy-to-use 12-fold fixed-bed fermenter system and best suitable for the parallel-cultivation of sensitive animal, human and other shear-sensitive cells which are without stable cell-wall. The system is used in the production of monoclonal antibodies, cultivation of adherent and recombinant cells and the use in the cell-physiological studies of tissue cells such as tumour cells, primary cells, stem cells, liver and kidney cells. The fixed-bed system is equipped with the needed measurement and control engineering, probes and sensors, peristaltic pumps, gas supply, control program and computer for the saving, evaluation and transfer of the data to other computers. The fixed-bed reactors are made of Duran glass and are fitted space-saving in the middle of a compact 1.5 l media conditioning vessel. The conditioning vessel is made of Duran glass also. This makes it possible to watch, to steer and to check the development of the cell cultivation better. The lid, the in- and exits are made of insensitive Peek material to protect the sensitive cells from damages by free metal molecules from the usual metal lids. The fixed-bed material consists of highly porous glass sinter pearls or another suitable carrier material and is in the fixed-bed reactors. The cells are transferred to the surface of the carrier material in the fixed-bed reactors. They grow and increase on, around and between the carrier materials and can be used for further tests and examinations.

• Depending on a cell-types and growth-needs "Multiferm" is best suitable for the parallel cultivation of the same or different cell lines which grow under the same or almost the same growth-conditions.
• The Fermenter system is excellently suitable for the pretesting and testing of medicine, biotechnology, pharmaceutical and food industry.

• 	medorex radially fluent fixed-bed bioreactor Fixed-bed bioreactor contains outer chamber and a central pipe which contains drillings in the sector of the fixed-bed. The Fixed-bed is held by two sieve walls . The culture medium is prepared and enriched with oxygen in the Outer chamber.
  	Status: 06-24-2011 pdf download (242 kB)