Scale-Up of Fixed-Bed Reactors for the Cultivation of Animal Cells
Advantages of mini fixed-bed reactors
- Immobilization on carriers
- Essential for adherent cell lines, low shear stress, retention of the cells in the system, high cell densities.
- Simple operation
- Easy inoculation process, no moving parts in the reactor, continuous operation over months.
- Compact construction
- A compact and easy to handle design is achieved by inserting the fixed-bed within the conditioning vessel. This also saves a second heating for the fixed-bed.
- Easy scale-up (for more information see the following PDF file)
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medorex small-scale fixed-bed systems
Small-scale fixed-bed systems are operated by pumping the medium axially through the fixed-bed. However, because of oxygen limitation the maximal length is limited to approx.
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Status: 02-22-2011  pdf download (304 kB)
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